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The antibacterial activity of TetmosolR, Dudu OsunR, DettolR, Life BuoyR and TuraR were evaluated against Stapylococcus aureus, Pseudomonas specie, Salmonella typhi, Klebsiella specie, Streptococcus specie and Proteus vulgaris obtained from infected wounds of patients from Delta State University health centre Abraka. The antimicrobial activity of various dilutions of the soap samples was evaluated by the Agar Diffusion. From the results obtained, Dudu OsunR and Life Buoy had the highest Zone of Inhibition (19 mm) at 10 mg/ml Least Zone of Inhibition was recorded for all Antiseptic soap at 100 mg/ml. Tetmosol was the most effective among the soaps and DettolR was the least effective while Pseudomonas specie was the most resistant pathogenic organism. In order of effectiveness, the performances of the soaps were; Dudu OsunR and TetmosolR 23% > life BuoyR 22% > TuraR 20%> DettolR 12% For MIC, all the antiseptic soaps had no MIC for Pseudomonas species; Dudu OsunR had MIC of 0.01mg/ml for Staphylococcus species and 10 mg/ml for the other test organisms; DettolR had MIC of 1mg/ml; TuraR, Life buoyR and TetmosolR had MIC of 10 mg/ml. For antibiotic susceptibility testing in the order of % antibiotic Sensitivity Proteus and Klebsiella (80%)>Streptococcus species (73.3%)>Staphylococcus aureus and Salmonella typhi (66.7%)>Pseudomonas species (46.7%). A total of 33.3% of all test organisms were sensitive to (Perfloxacin, Ciprofloxacin, Streptomycin, Septrin, and Tarivid) antibiotics. In the order of % antibiotic resistance, Pseudomonas species 53.3%>Salmonella typhi, Staphylococcus aureus and Streptococcus species 33.3%>Proteus vulgaris and Klesiella species (20%). A total of 20% of all test organisms were resistant to (Ampiclox, Zinnacef,and Amoxicillin) antibiotics.