FORMULATING A PROBIOTIC TOOTHPASTE FOR VITAMIN B6 DELIVERY SYSTEM
Journal of International Research in Medical and Pharmaceutical Sciences, Volume 13, Issue 2,
Background: Nowadays the functions of toothpaste are more than removing oral cavities. Many toothpastes are formulated to promote whiter teeth or removal of bad breath as their proud specialty for each product. The fundamental function of the toothpaste is usually to remove leftover food from the oral cavity to prevent growing harmful oral bacteria. Recently, some toothpastes add probiotics for clamining many advantages. Certain beneficial bacteria such as Streptococcus salivarius prevents the growth of harmful mutants, thus minimises bad breath from the mouth.
Aims: The feasibility of intraorally delivering vitamin B6 by adding into the formulation of toothpaste was investigated because it was deemed to be an amazing match, considering the importance of regular administration of vitamin B6 without forgetting as usually done most patients.
Methodology: An emulsion-based toothpaste was formulated with a probiotic and vitamin B6, reinforced with chemical penetration enhancer azone and other typical ingredients. Various characteristics of our probiotic vitamin B6 toothpaste was compared with those of other commercial brand toothpastes. The chatracteristics include abrasiveness, scratchiness, spreadibility, pH, foaming, cleaning and antibacterial ability. And, a trans-epithelial electrical resistance (TEER) value was measured with Lumbricus terrestris skin.
Conclusion: The study concluded that our probiotic vitamin B6 toothpaste had comparable characteristics with other commercial toothpaste. TEER value demonstrated that our formulation had high feasibility of vitamin B6 delivery.
- vitamin B6
- drug delivery system
- penetration enhancer
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