MEDICINAL PLANTS FOR THE TREATMENT OF ALZHEIMER’S DISEASE: CURRENT TREATMENT & FUTURE PERSPECTIVE
Journal of International Research in Medical and Pharmaceutical Sciences, Volume 17, Issue 3,
Page 30-41
DOI:
10.56557/jirmeps/2022/v17i38008
Abstract
Alzheimer's disease (AD) is a disorder of brain which progressively weakens the cognitive function. It is occur due to formation of β amyloid plaques & neurofibrillary tangles, & cholinergic neurotransmitter degeneration. At present there is no cure for this disease but currently it can be controlled by using a drugs which symptomatically treat the AD involve N-methyl D-aspartate (NMDA) receptor antagonist (memantine) & Acetylcholinesterase inhibitors (AChEIs) (donepezil, rivastigmine, galantamine). Natural treatment comprising various medicinal plants & herbs are utilize to treat brain disorders like dementia, amnesia, and AD from ancient time. Preclinical & clinical studies both are confirmed the therapeutic potential of herbal product for inhibition of AD. Medicinal plants shown effectiveness against Alzheimer’s probably because of their pleiotropic & multiple action which involves antioxidants, anti-inflammatory & neuroprotective activity. In this present review we focuses on the therapeutic potential of various medicinal plants which significantly contributed for treating AD & memory deficits.
Keywords:
- Medicinal plants
- antioxidant
- neuroprotective action
- neurofibrillary tangles
How to Cite
HASHMI, A., SRIVASTAVA, V., & SINGHAL, P. (2022). MEDICINAL PLANTS FOR THE TREATMENT OF ALZHEIMER’S DISEASE: CURRENT TREATMENT & FUTURE PERSPECTIVE. Journal of International Research in Medical and Pharmaceutical Sciences, 17(3), 30–41. https://doi.org/10.56557/jirmeps/2022/v17i38008
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Lippincott, Williams, Wilkins. "Alzheimer disease drugs." Nursing 2010 Drug Handbook. Philadelphia: Wolters Kluwer Health. 2010;546-551.
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Jayaprakasam B, Padmanabhan K, Nair MG. Withanamides in Withania somnifera fruit protect PC‑12 cells from beta‑ amyloid responsible for Alzheimer’s disease. Phytotherapy Research. 2010;24: 859‑63.
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Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Journal of Neuroscience. 2001;21: 8370-8377.
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fi brils, binds plaques, and reduces amyloid in vivo. Journal of Biological Chemistry. 2005;280:5892-5901.
Shinomol GK, Muralidhara, Bharath MM. Exploring the role of ‘Brahmi’ (Bocineopa monnieri and Centella asiatica) in brain function and therapy. Recent Patents on Endocrine, Metabolic and Immune Drug Discovery. 2011;5:33-49.
Singh HK, Dhawan BN. Effect of Bacopa monniera Linn. (Brahmi) extract on avoidance responses in rat. Journal of Ethnopharmacology. 1982;5:205-214.
Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. Journal of Ethnopharmacology. 2010;127:26-31.
Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S:Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus. Phytotherapy Research. 2000;14:174-179.
Limpeanchob N, Jaipan S, Rattana karuna S, Phrompittayarat W, Ingkaninan K:Neuroprotective eff ect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. Journal of Ethnopharmacology. 2008;120:112-117.
Warrier PK, Nambiar VPK, Ramankutty C, editors. Indian medicinal plants:a compendium of 500 species. India:Sangam Books. 1996;46(11).
Houghton P, Howes MJ. Natural products and derivatives affecting neurotransmission relevant to Alzheimer’s and Parkinson’s disease. Neurosignals. 2005;14(1-2):6-22.
Patwardhan B, Ashok DB, Chorghade M. Ayurveda and Natural Products Drugs Discovery. Current Science. 2004;86(6):789 – 799.
Andrzejewska J, Ignaczak S, Katańska-Kaczmarek A, Barzyk P. Crude fat content and fatty acid profile in the seeds of polish lines and cultivars of field pea (Pisum sativum L.): Pilot Study. EJPAU. 2015;18(4):07.
Kaura S, Parle M. Evaluation of nootropic potential of green peas in mice. Journal of Applied Pharmaceutical Science. 2017; 7(5):166-173.
Nemalapalli Y et al. Effect of ethanolic seed extract of Bauhinia purpurea linn on cognition in scopolamine induced Alzheimer’s disease rat’s model. Journal of Comprehensive Pharmacy. 2015;2(4):145-150.
Kumar A, Ilavarasan R, Jayachandran T, Decaraman M, Aravindha P. Phytochemical investigation on a tropical plant, Syzygium cumini from Kattupalayam, Erode district, Tamilnadu, South India. Pakistan Journal of Nutrition. 2009;8:83–85.
Rekha Namasivayam, Balaji Ramachandran, Deecaraman Munuswamy. Effect of aqueous extract of Syzygium cumini pulp on antioxidant defense system in streptozotocin induced diabetic rats. Iranian Journal of Pharmacology & Therapeutics. 2008;7:137–145.
Modi DC, Patel JK, Shah BN, Nayak BS. Antiinflammatory activity of seeds of Syzygium cumini linn. American Journal of Pharmaceutical Education. 2010;1:68–70.
Alikatte KL, et al. Antiamnesic activity of Syzygium cumini against scopolamine induced spatial memory impairments in rats. Brain & Development. 2012;34:844–851.
Zhang L, Huang Y, Lu L, Wai MSM, Chan WM, Yew DT. Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis. Neurochemical Research. 2012;37:911-919.
Iswantini D, Ramdhani TH, Darusman LK. In vitro inhibition of celery (Apium graveolens L.) extract on the activity of Xanthine oxidase and determination of its active compound. Indonesian Journal of Chemistry. 2012;12(3):247-254.
Misic D, Zizovic I, Stamenic M, Asanin R, Ristic M, Petrovic SD, Skala D. Antimicrobial activity of celery fruit isolates and SFE process modeling. Biochemical Engineering Journal. 2008;42:148-152.
Phetcharat B, Wanida S, Supita T, Pennapa, C. Ameliorative effect of Apium graveolens Linn on scopolamine-induced amnesia mice. The International Conference on Herbal and Traditional Medicine. 2015;82-93.
Gokhale AB, Damre AS, Kulkarni KR, Saraf MN. Preliminary evaluatin of anti-inflammatory and anti-arthritic activity of S. lappa, A. speciosa and A. aspea. Phytomedicine. 2002;9:433-437.
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