Antihyperglycemic and Anticholesterolemic Effects of Fig Leaf (Ficus glomerata Linn.) Extract in Alloxan Induced Diabetes in Wistar Albino Rats
PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, Volume 24, Issue 1-2,
Page 30-41
DOI:
10.56557/pcbmb/2023/v24i1-28169
Abstract
In this present scenario,medicinal plants are becoming popular for the treatment of various diseases all over the world. Some of them are being traditionally used in diabetes for human welfare. Diabetes is a common endocrine disorder that impairs glucose metabolism resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy, neuropathy and causing neurological disorder due to perturbation in utilization of glucose. In the present study, an effort has been made to assess the antidiabetic properties of Ficus glomerata leaf extract treatment in alloxan monohydrate induced diabetic albino rats. Present study refers to the medicinal plant Ficus glomerata leaf metabolites compared to insulin treatment animal model. Diabetes was induced in albino rats with the help of alloxan monohydrate (150 mg/kg) intraperitoneal saline injection. Present study was carried out to evaluate the anti-diabetic activity of Ficus glomerata aqueous leaf extract in diabetic albino rats for 4 week treatment. The treatment with aqueous leaf extract at high dose (1g/kg) significantly decreased circulating blood glucose concentration in comparison to mild dose (500mg/kg) and low dose (100mg/kg) respectively in diabetic rats. The aqueous leaf extract also improved the hematological picture, weight, biochemical profile and glucose intolerance lowering effects in diabetic animal models. In conclusion, Ficus glomerata leaf metabolites have tremendous antidiabetic potential in alloxan-induced experimental models. The results suggest the possibility that Ficus glomerata leaves metabolites to cure diabetes in herbal medicine.
- Diabetes
- alloxan
- ficus glomerata
- blood glucose
How to Cite
References
Oze G, Nwanjo H, Oze R, Akubugwo E, Orisakwe E, Aka P. Reproductive impairment associated with ethanolic extract of Alstonia boone (De-wild) stem bark in male rats. The internet Journal of Laboratory Medicine. 2008;3(1):1-10.
King H, Aubert RE, Herman WH. Global burden of diabetes, 1995- 2025 Prevalence, numerical estimates and Projection. Diabetes Care. 1998;21:1414-1431.
Gray AM, Abdel-Wahab YH, Flatt PR. The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions In vitro. J Nutr. 2000;130(1):15-20. DOI: 10.1093/jn/130.1.15. PMID: 10613759.
Lenzen S. The mechanism of alloxan and streptozotocin induced diabetes. Diabetologia. 2008;55:216-226.
Lenzen S, Panten U. Alloxan: History and mechanism of action. Diabetologia. 1998;31:337-342.
Joseph B, Raj SJ. Phytopharmacological & phytochemical properties of three Ficus species: An overview. Int.J. Pharma & BioSci. 2010;1(4):246-253.
Aruna RV, Ramesh B, Kartha VN. Effect of beta carotene on protein glycosylation in alloxan induced diabetic rats. Indian J Exp Biol. 1999;37(4):399-401. PMID: 10641177.
Janet Hoff. Method of blood collection in the mouse. Techniques. 2000;29(10):47-53.
Du Vigneaud V, Karr WG. Carbohydrate utilization. Rate of disappearance of D glucose from the blood. J Biol Chem. 1925;66:281-300.
Al-Awadi FM, Khattar MA, Gumaa KA. On the mechanism of the hypoglycaemic effect of a plant extract. Diabetologia. 1985;28(7):432-4. DOI: 10.1007/BF00280886. PMID: 3899826
Sezik E, Aslan M, Yesilada E, Ito S. Hypoglycemic activity of Gentiana olivieri and isolation of the active constituent through bioassay directed fractionation techniques. Life Sci. 2005;76:1223-1238.
Sperling MA, Saunders PA. Diabetes mellitus in: R.E. Behrman RM, Kliegman HB, Jenson (Eds). Nelson Textbook of Pediatrics. 2000;1767-1791.
Mahomed IM, Ojewole JA. Methods Find Exp. Clin. Pharmacol. 2003;25:617-623.
Prince SM, Menon VP. Hypoglycemic and other related actions of Tinospora cordifolia roots in alloxan induced diabetic rats. J. Ethno Pharmacol. 2000;70:9-15.
Jelodar G, Mohsen M, Shahram S. Effects of walnut leaf, Coriander and Pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats. African J. Traditional, Complementary and Alternative Medicines. 2003;3:299-305.
Grover JK, Vats V, Rathi SS. Antihyperglycemic effect of Eugenia Jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol. 2000;73:461470.
Shanmugasundaram KR, Panneerselvam SP, Shanmugasundaram ERB. Enzyme changes and glucose utilization in diabetic rabbit. The effect of Gymnema sylvestre. R. Br, J. Ethnopharmacol. 1983 7: 205- 216.
Begum N, Shanmugasundaram KR. Tissue phosphates in experimental diabetes. Arogya; J. Health Sci. 1978; 4:129-139.
Saba AB, Oyagbemi AA, Azeez OI. Antidiabetic and haematinic effects of Prquentina nigrescens on alloxan induced type-1 diabetes & normocytic normochromic anemia in Wistar rats. African Health Science. 2010;10(3):276-282.
Shachi K, Kumar S, Prasad NK. Anti-diabetic and Anti-cholesterolmic effects of bettergourd (Momordica charantia linn) fresh fruit juice metabolites to cure Alloxan Monohydrate induced Type-1 diabetes in Albino Rats. Adv Tech Biol Med. 2020;8:271. DOI: 10.4172/2379-1764.1000271
Patil UK, Tripathy MK. Antidiabetic activity of ethanolic extract of heartwood of bijasar (Pterocarpus marsupium Roxb.) in streptozotocin-nicotinamide induced type 2 diabetic rats. Int J Pharm Sci Res. 2014;5(12):5572- 5577.
DOI:10.13040/IJPSR.0975-8232.5
Lakshmi RK, Divya BT, Mini S. Cissus quadrangularis extract attenuates hyperglycemia-mediated oxidative stress in streptozotocin-induced diabetic rats. Redox Rep. 2014;19(5):214-20. DOI: 10.1179/1351000214Y.0000000096
Epub 2014 Jun 19. PMID: 24946070
Kumar S, Shachi K., Kush K, Dubey NK. Antidiabetic and hematinic effects of Trigonella foenum-graecum (fenugreek) in alloxan induced diabetic albino rats. J Zool. 2012;32:249-251.
Kumar S, Shachi K, Dubey NK, Dubey U. Anti-Diabetic and Haematinic Effects of BeetRoot Juice (Beta vulgaris L.) in Alloxan Induced Type-1 Diabetic Albino Rats. J Diab Res Ther. 2020;6(1).
Available:dx.doi.org/10.16966/2380-5544.150
Mandal SC, Maity TK, Das J. Pal M, Saha BP. Hepatoprotective activity of Ficus racemosa leaf extract on liver damage caused by carbon tetrachloride in rats. Phototherapy Research. 1999;13(5):430-430.
Rorsman P. The pancreatic B-cell as a fuel sensor. Diabetologia. 1997;40: 487-495.
Silverman, Harold. The Pill Book. 9th Edition, Pill Book Company, New York; 1986.
Satyavati GV, Raina MK, Sharma M. Medicinal plants of India. Indian Council of Medical Research New Delhi. 1976; 415-421.
-
Abstract View: 99 times
PDF Download: 3 times
